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Valtrex is offered in 500 mg and 1gram tablets, the active ingredient being Valaciclovir hydrochloride. It can help reduce the number of outbreaks you have. Once-daily Valtrex is also the only medication proven to reduce the amount of time for an outbreak if taken soon enough. Aciclovir that has greater oral bioavailability than aciclovir. Valtrex has shown promise as a treatment for infectious mononucleosis and is preventatively administered in suspected cases of herpes virus exposure. Valaciclovir is a drug, an esterified version of aciclovir that has greater oral bioavailability than aciclovir. Valtrex is a very expensive drug if you do not have generic version called Valaciclovir.