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Synthroid is to be used only when clearly needed during pregnancy. It is also used to treat the enlargement of the thyroid gland does not produce enough thyroid hormone. Common side effects produced by Synthroid include fatigue, increased appetite, weight loss, heat intolerance, and fever. If you need to take Synthroid because of a thyroid hormone deficiency, you can take the Synthroid 50 mg tablet, which is made without color additives.