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Will said: "Clopidogrel should be used carefully if you suffer from problems inside the eyes, have bleeding problems due to narrowing and hardening of the arteries. Plavix, now the world's second best-selling drug, received FDA approval to thin the blood and prevent clots that can occur with certain heart or blood vessels. Clopidogrel can decrease the chance of a heart attack or stroke in certain groups of people at high risk for these events."