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This medicine. Celecoxib is used to treat arthritis, acute pain, and nausea versus prescription ibuprofen and naproxen. The shortest possible time necessary to relieve your symptoms. Celecoxib is a nonsteroidal anti-inflammatory drug that is used to treat arthritis, acute pain, and nausea versus prescription ibuprofen and naproxen. For the management of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Celecoxib differs from other NSAIDs in that it causes less inflammation and ulceration of the stomach and intestine and does not interfere with the clotting of blood. It is important to keep taking it as instructed by your doctor. This drug may rarely cause serious liver disease. Celecoxib is used to reduce pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.