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Take Cipro tablet with a full glass of water and juices to increase drug's effectiveness and minimize adverse drug interaction. This medication may cause stomach upset, loss of appetite, diarrhea, headache or dizziness during the first few days as your body adjusts to the medication. Cipro is prescribed differently depending on what bacteria and disease is being treated. Drink a lot of water and juices to increase drug's effectiveness and minimize adverse drug interaction. Ciprofloxacin is an effective medicine which is usually used as a last resort for serious severe infections. Cipro should not be taken with or without food, however best absorption occurs when taken two hours after a meal. Because Cipro is effective only for certain types of bacterial infections, before beginning treatment your doctor may perform tests to identify the specific organisms causing your infection. Cipro should not be taken with dairy products such as milk or yogurt or juices.